HAE patients experience recurrent episodes of swelling in the hands, feet, gastrointestinal tract, genitals and larynx (throat) that can last from two to five days. The frequency of and severity of attacks may vary dramatically among patients, even those in the same family.
HAE – related swelling is NOT the same as swelling caused by allergies and cannot be treated as an allergic reaction. Antihistamines and corticosteroids are not effective treatments for C1 Inhibitor deficiency. About 25% of HAE patients experience a non-itching red rash that often occurs before or during an HAE attack.