The gene defect that causes HAE is hereditary. Children of parents with HAE have a 50/50 chance of inheriting the disease if one parent has HAE. A person cannot be a “carrier” of the HAE gene. HAE does not skip generations, which means that the children of non-patients will not inherit the disease. For the most reliable test result, children should be at least one year old for C1-Inhibitor testing.
It is important to note that 25% of HAE patients do NOT have a family history of the disease. This means that the gene became spontaneously defective during conception. These HAE patients can pass on HAE to their children.